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Updated: Apr 27, 2026

A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy
Published on: January 30, 2019
Lipophilicity - beyond octanol/water: a short comparison of modern technologies
Thorsten Hartmann1, Johannes Schmitt1
1NIMBUS Biotechnologie GmbH, Eilenburger Str. 4, 04317 Leipzig, Germany.
Abstract:
Sorting out new chemical entities (NCE) with inappropriate absorption, distribution, metabolism, excretion (ADME) behaviour at an early stage of drug discovery and development is a major challenge in pharmaceutical profiling. An accepted strategy to predict absorption is the measurement of the permeability of a drug candidate. One step earlier the lipophilicity of a compound is determined, which is directly related to permeability and fraction absorbed. Here, we compare today's state of the art technologies for a fast measurement of lipophilicity.:
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