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Updated: Apr 27, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles
Published on: March 2, 2020
Smart polymeric micelles for gene and drug delivery
Nobuhiro Nishiyama1, Younsoo Bae2, Kanjiro Miyata2
1Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Abstract:
Polymeric micelles, supramolecular assemblies of block copolymers, are useful nanocarriers for the systemic delivery of drugs and genes. Recently, novel polymeric micelles with smart functions, such as targetability and stimuli-sensitivity, have emerged as promising carriers that enhance the efficacy of drugs and genes with minimal side effects. This review focuses on the construction and characteristic behaviors of intracellular environment-sensitive micelles that selectively exert drug activity and gene expression in live cells.:
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