Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colonic drug delivery.

Abraham Rubinstein1

  • 1The Hebrew University of Jerusalem, Faculty of Medicine, School of Pharmacy, P.O. Box 12065, Jerusalem 91120, Israel.

Drug Discovery Today. Technologies
|July 2, 2014
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synchronizing the release rates of topotecan and paclitaxel from a self-eroding crosslinked chitosan - PLGA platform.

International journal of pharmaceutics·2022
Same author

Controlling the release rate of topotecan from PLGA spheres and increasing its cytotoxicity towards glioblastoma cells by co-loading with calcium chloride.

International journal of pharmaceutics·2021
Same author

Synchronizing the release rates of salicylate and indomethacin from degradable chitosan hydrogel and its optimization by definitive screening design.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2018
Same author

Increasing the affinity of cationized polyacrylamide-paclitaxel nanoparticles towards colon cancer cells by a surface recognition peptide.

International journal of pharmaceutics·2017
Same author

The effect of linker type and recognition peptide conjugation chemistry on tissue affinity and cytotoxicity of charged polyacrylamide.

Journal of controlled release : official journal of the Controlled Release Society·2016
Same author

The anti-inflammatory activity of a novel fused-cyclopentenone phosphonate and its potential in the local treatment of experimental colitis.

Gastroenterology research and practice·2015
Same journal

Advances in virtual screening.

Drug discovery today. Technologies·2024
Same journal

Integration of virtual and physical screening.

Drug discovery today. Technologies·2024
Same journal

A technical overview of supercritical fluid chromatography-mass spectrometry (SFC-MS) and its recent applications in pharmaceutical research and development.

Drug discovery today. Technologies·2021
Same journal

Mass spectrometry based approaches and strategies in bioanalysis for qualitative and quantitative analysis of pharmaceutically relevant molecules.

Drug discovery today. Technologies·2021
Same journal

Drug discovery from natural products using affinity selection-mass spectrometry.

Drug discovery today. Technologies·2021
Same journal

Editorial for the role(s) of MS in drug research and development.

Drug discovery today. Technologies·2021
See all related articles

Colon-specific drug delivery research offers few viable techniques due to unclear therapeutic needs for colon targeting. Critical analysis of current methods and novel ideas may reveal future prospects for targeted therapies.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Gastrointestinal Pharmacology

Background:

  • Colon-specific drug delivery aims to improve therapeutic efficacy and reduce systemic side effects.
  • Despite 15 years of research, a limited number of clinically viable colon-targeting techniques have emerged.
  • The lack of progress stems from uncertainty about the actual therapeutic need for colon-specific drug administration.

Purpose of the Study:

  • To critically analyze existing colon-specific drug delivery technologies.
  • To explore novel, medically-grounded ideas for colon targeting.
  • To identify future prospects in the field of colon-specific drug delivery.

Main Methods:

  • Review and critical analysis of published research on colon-specific drug delivery.

Related Experiment Videos

  • Evaluation of current technologies based on scientific evidence and clinical applicability.
  • Conceptualization of new strategies informed by medical needs and technological advancements.

    • Main Results:

    • A significant gap exists between proof-of-concept studies and clinically applicable colon-targeting methods.
    • Ambiguity in demonstrating the therapeutic necessity for colon-specific drug delivery hinders technological advancement.
    • Existing techniques face challenges related to efficacy, safety, and patient compliance.

    Conclusions:

    • Further research should focus on clarifying the therapeutic rationale for colon targeting.
    • Innovation in colon-specific drug delivery requires a combination of technological refinement and a clear understanding of clinical needs.
    • Future prospects lie in developing novel approaches that address both technological limitations and therapeutic uncertainties.