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Nanoparticle uptake by the oral route: Fulfilling its potential?
1Centre for Drug Delivery Research, The School of Pharmacy, University of London, London, UK WC1N 1AX.
Drug Discovery Today. Technologies
|July 2, 2014
Summary
Nanoparticle absorption from the gut depends on particle size, type, and surface modifications. Post-absorption events, like translocation, are critical for cellular uptake in the gastrointestinal tract.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmacokinetics
Background:
- Gastrointestinal absorption of nanoparticles is a key factor in drug delivery and toxicology.
- Understanding nanoparticle uptake mechanisms is crucial for predicting their fate in the body.
Purpose of the Study:
- To review the critical parameters influencing nanoparticle absorption from the gastrointestinal tract.
- To highlight the importance of post-absorptive events in nanoparticle bioavailability.
Main Methods:
- Literature review of recent historical perspectives on nanoparticle absorption.
- Analysis of factors affecting nanoparticle uptake and translocation.
Main Results:
- Particle diameter, nature, and surface modification (ligand targeting) significantly influence nanoparticle uptake.
- Translocation processes post-absorption are as important as initial cellular uptake.
Conclusions:
- Effective nanoparticle delivery requires careful consideration of both uptake and post-absorption translocation.
- Further research into translocation mechanisms is needed to optimize nanoparticle-based therapies.
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