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Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
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Polymeric nanoparticle technologies for oral drug delivery
Eric M Pridgen1, Frank Alexis2, Omid C Farokhzad3
1School of Medicine, Stanford University, Stanford, California.
Summary
Oral biologics face challenges like stomach acid and enzymes. Polymeric nanoparticles offer a solution by protecting drugs and improving intestinal absorption for easier patient treatment.
Area of Science:
- Biotechnology and Pharmaceutical Sciences
- Drug Delivery Systems
- Nanomedicine
Background:
- Biologics are crucial therapeutics but often require injections.
- Oral administration offers patient convenience but faces physiological barriers.
- Gastrointestinal conditions like low pH and enzymes degrade biologics.
Purpose of the Study:
- To review advances in polymeric nanoparticles for oral biologic delivery.
- To explore strategies overcoming intestinal transport barriers.
- To assess the clinical translation potential of these nanocarriers.
Main Methods:
- Review of recent scientific literature on polymeric nanoparticles for oral drug delivery.
- Analysis of nanoparticle formulations designed to protect biologics.
- Evaluation of studies addressing intestinal epithelium permeability challenges.
Main Results:
- Polymeric nanoparticles protect biologics from gastrointestinal degradation.
- Nanoparticle strategies show promise in enhancing intestinal absorption.
- Recent developments focus on overcoming critical transport barriers.
Conclusions:
- Polymeric nanoparticles are a promising strategy for oral biologic delivery.
- Further research is needed to optimize nanoparticle design for clinical use.
- Successful oral delivery systems could significantly improve patient compliance and treatment outcomes.
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