Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response.

Science immunology·2026

Same author

SomaVR: A low-cost virtual reality platform and implementation framework for medical education in resource-limited settings.

PLOS digital health·2026

Same author

Effects of social dominance on perineuronal nets in medial prefrontal cortex and basolateral amygdala.

Physiology & behavior·2026

Same author

Synthesis and Biological Evaluation of the Complete Octapeptin Natural Product Series.

Journal of medicinal chemistry·2026

Same author

Rapid profiling of polymyxin B susceptibility in Gram-negative bacteria with a novel polymyxin-derived fluorescent probe.

Journal of advanced research·2026

Same author

Standing strong: Effects of social dominance on neural activity and defeat-induced social avoidance in female Syrian hamsters.

Hormones and behavior·2025

Same journal

Advances in virtual screening.

Drug discovery today. Technologies·2024

Same journal

Integration of virtual and physical screening.

Drug discovery today. Technologies·2024

Same journal

A technical overview of supercritical fluid chromatography-mass spectrometry (SFC-MS) and its recent applications in pharmaceutical research and development.

Drug discovery today. Technologies·2021

Same journal

Mass spectrometry based approaches and strategies in bioanalysis for qualitative and quantitative analysis of pharmaceutically relevant molecules.

Drug discovery today. Technologies·2021

Same journal

Drug discovery from natural products using affinity selection-mass spectrometry.

Drug discovery today. Technologies·2021

Same journal

Editorial for the role(s) of MS in drug research and development.

Drug discovery today. Technologies·2021

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 27, 2026

Avidity-based Extracellular Interaction Screening AVEXIS for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions

Avidity-based Extracellular Interaction Screening AVEXIS for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions

Published on: March 5, 2012

Profiling molecular interactions using label-free acoustic screening.

Matthew A Cooper¹, Christopher Whalen¹

¹Akubio Ltd, Unit 181 Cambridge Science Park, Cambridge, UK CB4 0GJ.

Drug Discovery Today. Technologies

|July 2, 2014

Summary

This summary is machine-generated.

Researchers need fast, accurate protein interaction analysis for drug development. Resonant Acoustic Profiling (RAP™) offers a label-free method to characterize these molecular interactions, potentially transforming assay performance.

More Related Videos

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors

Published on: April 29, 2022

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

Related Experiment Videos

Last Updated: Apr 27, 2026

Avidity-based Extracellular Interaction Screening AVEXIS for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions

Avidity-based Extracellular Interaction Screening AVEXIS for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions

Published on: March 5, 2012

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors

Published on: April 29, 2022

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

Area of Science:

Biochemistry
Biophysics
Pharmacology

Background:

Increasing interest in proteins as therapeutic drug candidates.
Growing need for precise characterization of protein-protein and protein-receptor interactions.
Current assay methods may lack speed or accuracy for complex molecular profiling.

Purpose of the Study:

To introduce Resonant Acoustic Profiling (RAP™) as a novel label-free analysis technique.
To highlight RAP™'s potential to improve the characterization of molecular interactions.
To demonstrate RAP™'s capability to generate new information in drug discovery assays.

Main Methods:

Utilized Resonant Acoustic Profiling (RAP™), a label-free analytical technology.
Focused on characterizing molecular interactions, including protein-protein and protein-receptor binding.
Employed Akubio's RAP™ system for advanced assay performance.

Main Results:

RAP™ provides a label-free approach for molecular interaction analysis.
The technique demonstrates potential for enhanced assay performance.
Novel insights into molecular interactions can be generated using RAP™.

Conclusions:

Resonant Acoustic Profiling (RAP™) represents a significant advancement in label-free interaction analysis.
This technology has the potential to revolutionize how molecular interaction assays are conducted.
RAP™ offers a valuable tool for researchers investigating protein therapeutics.