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Metabolomic Analysis of Rat Brain by High Resolution Nuclear Magnetic Resonance Spectroscopy of Tissue Extracts

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Published on: September 21, 2014

Slow-MAS NMR: A new technology for in vivo metabolomic studies

Robert A Wind¹, Jian Z Hu¹, Paul D Majors¹

¹Pacific Northwest National Laboratory, P.O. Box 999, MS K8-98, 3335 Q Avenue, Richland, WA 99352, USA.

Drug Discovery Today. Technologies

|July 2, 2014

Abstract:

Obtaining detailed in vivo metabolic information has been identified as key elements of better understanding the efficacy and toxicity of new therapies. A new nuclear magnetic resonance (NMR) technology called LOCMAT is reported in this paper that yields substantially increased spectral resolution in spatially localized in vivo H NMR metabolite spectra, as illustrated by measurements in the liver of a live mouse. LOCMAT promises to significantly enhance the utility of NMR spectroscopy for biomedical research.:

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