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A structural perspective of compensatory evolution.

Dmitry N Ivankov1, Alexei V Finkelstein2, Fyodor A Kondrashov3

  • 1Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), 88 Dr. Aiguader, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain; Laboratory of Protein Physics, Institute of Protein Research of the Russian Academy of Sciences, 4 Institutskaya str., Pushchino, Moscow Region, 142290, Russia.

Current Opinion in Structural Biology
|July 2, 2014
PubMed
Summary
This summary is machine-generated.

Molecular evolution reveals how protein functions develop. Compensatory substitutions, where one change depends on others, are key, but their basis is often unclear. This review explores structural biology

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Area of Science:

  • Molecular Evolution
  • Structural Biology
  • Protein Function

Background:

  • Molecular evolution studies how protein functions emerge and change over time.
  • Compensatory substitutions, where amino acid changes at one site depend on residues at other sites, are increasingly recognized.
  • The molecular or structural basis for these compensatory events remains largely unknown.

Purpose of the Study:

  • To review studies at the intersection of structural biology and molecular evolution.
  • To elucidate the molecular and structural underpinnings of compensatory evolution.
  • To highlight how structural data enhances the understanding of evolutionary processes.

Main Methods:

  • Literature review of studies integrating structural biology and molecular evolution.
  • Analysis of evolutionary data in conjunction with structural information.
  • Examination of case studies demonstrating compensatory evolution.

Main Results:

  • Structural biology provides insights into the mechanisms of compensatory evolution.
  • Evolutionary data can guide and inform structural studies.
  • Integration of both fields reveals novel aspects of protein functional adaptation.

Conclusions:

  • Structural and evolutionary data are complementary in understanding protein evolution.
  • Compensatory evolution is a significant factor in protein functional diversification.
  • Further integration of structural biology and molecular evolution is crucial for advancing the field.