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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Updated: Apr 27, 2026

Author Spotlight: Standardizing Mouse In Vivo PET Imaging with Body Conforming Molds and Automated Analysis
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The enabling technologies needed for PET-based molecular imaging to support drug development.

Terry Jones1

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Positron Emission Tomography (PET) imaging for drug development requires more than just a cyclotron and scanner. Integrating additional technologies significantly enhances the quality and value of pharmacodynamic and pharmacokinetic data.

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Area of Science:

  • Molecular imaging
  • Drug development
  • Pharmacokinetics
  • Pharmacodynamics

Background:

  • Positron Emission Tomography (PET) is crucial for drug development.
  • Current belief oversimplifies PET requirements, focusing only on cyclotrons and scanners.
  • Full exploitation of PET for detailed tissue analysis is often limited.

Purpose of the Study:

  • To review the essential technologies beyond cyclotrons and PET scanners for comprehensive drug development.
  • To highlight advancements enabling detailed pharmacodynamic and pharmacokinetic measurements.
  • To underscore the integrated impact of these technologies on data quality.

Main Methods:

  • Literature review of PET-based molecular imaging technologies.
  • Analysis of supporting systems for drug development applications.
  • Examination of ongoing technological advancements in the field.

Main Results:

  • Identified numerous critical technologies beyond basic PET hardware.
  • Detailed the role of these technologies in pharmacodynamic and pharmacokinetic studies.
  • Highlighted emerging developments across various technological areas.

Conclusions:

  • PET imaging for drug development necessitates a sophisticated ecosystem of technologies.
  • Continuous innovation in these supporting technologies promises significant improvements.
  • Integrated advancements enhance the precision and utility of PET data in drug discovery.