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PET studies in drug development: Methodological considerations
Vincent J Cunningham1, Christine A Parker2, Eugenii A Rabiner2
1Translational Medicine and Genetics, GlaxoSmithKline, 891-995 Greenford Road, Greenford, Middlesex, UK UB6 7HE.
Abstract:
Positron emission tomography (PET), as an in vivo pharmacological imaging tool in experimental medicine, is playing an increasing role in drug development. There are two areas where PET is particularly useful in this respect, namely biodistribution and drug occupancy studies. Radiotracer design, the properties of the molecular targets which can be studied and the quantitative estimation of pharmacological endpoints will be discussed in relation to these applications, with particular reference to studies in brain.:
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