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Updated: Apr 27, 2026
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MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease
Published on: February 14, 2012
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Imaging studies in drug development: Parkinson's disease.
1MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, Cyclotron Building, Hammersmith Hospital, Du Cane Rd, London, UK W12 0NN.
Drug Discovery Today. Technologies
|July 2, 2014
Summary
Positron emission tomography (PET) and single photon emission computed tomography (SPECT) aid in diagnosing parkinsonian disorders. These imaging techniques also track treatment effects and drug targets in the brain.
Area of Science:
- Neuroimaging
- Neurology
- Pharmacology
Background:
- Parkinsonian disorders present diagnostic challenges.
- Monitoring therapeutic interventions in neurodegenerative diseases requires reliable methods.
Purpose of the Study:
- To highlight the utility of PET and SPECT in diagnosing parkinsonian disorders.
- To demonstrate the role of PET and SPECT in evaluating novel neuroprotective and restorative agents.
- To showcase the application of PET and SPECT in understanding treatment-related complications.
Main Methods:
- Utilizing Positron Emission Tomography (PET) for in-vivo imaging.
- Employing Single Photon Emission Computed Tomography (SPECT) for brain imaging.
- Analyzing dopamine level changes indirectly through PET and SPECT.
Main Results:
- PET and SPECT confirm diagnoses when uncertainty exists.
- These imaging modalities serve as biomarkers for treatment efficacy.
- PET confirms drug target engagement and dose-occupancy.
Conclusions:
- PET and SPECT are valuable tools for diagnosing and monitoring parkinsonian disorders.
- These techniques facilitate the assessment of novel therapeutic strategies.
- PET and SPECT offer insights into the neurochemical basis of treatment complications.
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