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Updated: Apr 27, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
Integrating disease knowledge and technology to deliver protein targets and biomarkers into drug discovery projects
Thomas E Fehniger1, Thomas Laurell2, György Marko-Varga1
1Department of Biological Sciences, AstraZeneca R&D, Lund, Sweden.
Abstract:
Biomarker discovery is dependent upon two disciplines: the field of clinical bioanalysis linked to disease aetiology and the application of high level technology platforms for identifying proteins/peptides in complex samples. However, diagnostic biomarker measurements require certain definitions of context that can only be achieved by combining protein science with clinical science. The evaluation of biomarkers requires careful attention to match (1) a specific biological question with (2) the appropriate clinical sample and (3) high resolution technology systems which link protein identities to clinical informatics.:
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