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Oleic Acid, deglycosylated vitamin D-binding protein, nitric oxide: a molecular triad made lethal to cancer

Marco Ruggiero1, Emma Ward2, Rodney Smith2

  • 1Department of Experimental and Clinical Biomedical Sciences, University of Firenze, Firenze, Italy Immuno Biotech Ltd, Guernsey, Channel Islands, UK.

Anticancer Research
|July 2, 2014
PubMed
Abstract

Insights

Oleic acid-GcMAF complexes show promise in reducing tumor volume by 25% in advanced cancer patients. This integrative immunotherapy approach stimulates the immune system with minimal side effects.

Area of Science:

  • Oncology
  • Immunotherapy
  • Nutritional Science

Background:

  • Oleic Acid (OA) exhibits anticancer properties through protein interactions.
  • Gc protein-derived macrophage activating factor (GcMAF) inhibits cancer proliferation and metastasis.
  • OA-GcMAF complexes were synthesized to synergize anticancer effects and stimulate nitric oxide (NO) release.

Observation:

  • Advanced cancer patients received OA-GcMAF integrative immunotherapy.
  • Treatment included a specific diet, fermented milk, Vitamin D3, omega-3 fatty acids, and low-dose aspirin.
  • Tumor volume was assessed using ultrasonography.

Findings:

  • A significant decrease in tumor volume of approximately 25% was observed.
  • The combination therapy demonstrated effective immune system stimulation.
  • Tumor reduction was achieved without apparent harmful side effects.

Implications:

  • OA, GcMAF, and NO can be effectively combined for cancer treatment.
  • This approach offers a potential strategy for immune stimulation and tumor reduction in advanced cancer.
  • Further research into this integrative immunotherapy is warranted.
Keywords:
Gc protein-derived macrophage activating factorOleic acidhuman cancermacrophagesnitric oxidevitamin D

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