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Third-line trabectedin for a metastatic desmoplastic small round cell tumour treated with multimodal therapy

Anna Elisabetta Brunetti1, Sabina Delcuratolo2, Vito Lorusso3

  • 1Medical Oncology Unit, National Cancer Institute "Giovanni Paolo II", Bari, Italy brunetti.ae@gmail.com.

Anticancer Research
|July 2, 2014
PubMed
Abstract

Insights

Trabectedin, a marine-derived drug, showed prolonged partial response in a heavily pre-treated patient with desmoplastic small round cell tumour (DSRCT). This suggests trabectedin as a potential option for managing this rare cancer.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Desmoplastic small round cell tumour (DSRCT) is an aggressive cancer primarily affecting young males, with limited treatment options and poor prognosis.
  • Current DSRCT management involves intensive multi-agent chemotherapy, surgery, radiation, and potentially autologous stem cell transplantation or HIPEC.

Observation:

  • A single patient with heavily pre-treated DSRCT, refractory to conventional therapies, received third-line treatment with trabectedin.
  • Trabectedin is a marine-derived antineoplastic agent with multi-target activity.

Findings:

  • The patient experienced a prolonged partial response and an extended period of stable disease after trabectedin administration.
  • This response was observed following disease progression despite prior multi-agent chemotherapy, HIPEC, and surgery.

Implications:

  • Trabectedin demonstrates potential as a valuable component in the multimodal treatment strategy for DSRCT.
  • Further research is warranted to investigate the efficacy and impact of trabectedin in DSRCT management.
Keywords:
Chemotherapydesmoplastic small round cell tumourmultimodal therapytrabectedin

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