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Multiorgan dysfunction related to chronic ketamine abuse.

Joseph M Pappachan1, Binu Raj1, Sebastian Thomas1

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Chronic ketamine abuse poses significant health risks, affecting multiple organs. This case highlights severe cachexia, gastrointestinal issues, liver dysfunction, and acute kidney injury in a patient with long-term ketamine use.

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Area of Science:

  • Toxicology
  • Drug Abuse Research
  • Internal Medicine

Background:

  • Ketamine abuse is a growing global concern.
  • Recreational ketamine use can lead to dissociative states and hallucinations.
  • Chronic abuse is linked to multi-organ damage, including the brain, heart, liver, gastrointestinal, and genitourinary systems.

Observation:

  • A patient with a history of chronic ketamine abuse presented with severe symptoms.
  • The patient exhibited significant weight loss (cachexia).
  • Gastrointestinal, hepatobiliary, and renal systems were notably affected.

Findings:

  • The patient presented with severe cachexia.
  • Evidence of upper gastrointestinal tract involvement was observed.
  • Hepatobiliary dysfunction and acute kidney injury were diagnosed.

Implications:

  • This case underscores the severe systemic complications of chronic ketamine abuse.
  • Highlights the need for increased awareness and clinical vigilance for ketamine toxicity.
  • Emphasizes the potential for multi-organ failure in chronic ketamine users.