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Updated: Apr 27, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

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Acute lymphocytic leukemia with superimposed invasive aspergillosis and pneumopericardium successfully treated with

Carlos L Alviar1, Bryan Doherty1, Muthiah Vaduganathan1

  • 1Division of Cardiology, New York University Langone Medical Center, New York, NY (Alviar); Lennox Hill Hospital, New York, NY (Doherty); and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (Vaduganathan).

Proceedings (Baylor University. Medical Center)
|July 2, 2014
PubMed

Insights

A man with acute lymphocytic leukemia developed pericardial aspergillosis and pneumopericardium. Combination therapy with voriconazole and vancomycin led to symptom improvement, highlighting effective treatment for this rare complication.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Cardiology

Background:

  • Acute lymphocytic leukemia (ALL) is a hematologic malignancy.
  • Pericardial involvement in leukemia patients can lead to serious complications.
  • Fungal infections, such as aspergillosis, can occur in immunocompromised individuals.

Observation:

  • A 47-year-old man with ALL presented with a pericardial friction rub.
  • The patient developed pneumopericardium, suggesting a lung-pericardial space connection.
  • Bronchoalveolar lavage revealed methicillin-resistant Staphylococcus aureus and Aspergillus niger.

Findings:

  • Pericardial friction rub indicated pericardial aspergillosis.
  • Pneumopericardium was a complicating factor, possibly due to direct lung-pericardial communication.
  • Infection with both MRSA and Aspergillus niger was confirmed.

Implications:

  • This case highlights a rare presentation of pericardial aspergillosis in an ALL patient.
  • Combination therapy with voriconazole and vancomycin demonstrated efficacy.
  • Prompt diagnosis and treatment are crucial for managing such life-threatening complications.

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