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Serum lipids, apolipoproteins, and mortality among coronary artery disease patients

Ding Ding1, Xinrui Li2, Jian Qiu3

  • 1Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, China ; Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.

Biomed Research International
|July 2, 2014
PubMed

Insights

For coronary artery disease (CAD) patients, high-density lipoprotein cholesterol (HDL-C) shows a U-shaped effect on mortality. Low-density lipoprotein cholesterol (LDL-C) and LDL/HDL ratio strongly predict mortality risk.

Area of Science:

  • Cardiology
  • Lipid Metabolism
  • Atherosclerosis Research

Background:

  • The roles of LDL-C and HDL-C in atherosclerosis are debated in coronary artery disease (CAD) patients.
  • Understanding lipid profiles' impact on CAD prognosis is crucial for patient management.

Purpose of the Study:

  • To investigate the association between various lipid measurements and prognosis in CAD patients.
  • To determine which lipid factors and ratios are most predictive of mortality in this population.

Main Methods:

  • A cohort of 1916 CAD patients (aged 40-85) was analyzed.
  • Cox proportional hazards regression models assessed 6 lipid factors and 3 ratios against all-cause and cardiovascular disease (CVD) mortality.
  • Median follow-up was 3.1 years, with 147 total deaths (113 CVD).

Main Results:

  • HDL-C exhibited a U-shaped association with all-cause and CVD mortality.
  • Elevated LDL-C, apoB, LDL/HDL, and apoB/apoA-I ratios were linked to increased CVD mortality risk.
  • Reduced apoA-I levels correlated with higher CVD mortality.
  • LDL/HDL ratio and LDL-C demonstrated stronger associations with mortality than other proatherogenic markers in Chinese CAD patients.

Conclusions:

  • Lipid profiles have differential impacts on CAD prognosis.
  • LDL/HDL ratio and LDL-C are significant predictors of mortality in Chinese CAD patients.
  • Further research into lipid management strategies for CAD patients is warranted.

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