Characterization of genetic variation in the VGLL4 gene in anorexia nervosa

Toni-Kim Clarke1, Richard C Crist, Glenn A Doyle

  • 1aDepartment of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia bDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania cDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland dDepartment of Psychiatry, University of Minnesota, Minneapolis, Minnesota eNew York Presbyterian Hospital-Westchester Division, Weill Medical College of Cornell, University, White Plains, New York fEating Recovery Center, Denver, Colorado gDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina hNeuropsychiatric Research Institute, Fargo iDepartment of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota jDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles kCenter for Health Sciences, SRI International, Menlo Park lDepartment of Psychiatry, University of California at San Diego, San Diego mScripps Genomic Medicine, The Scripps Research Institute, La Jolla, California nDepartment of Psychology, Florida State University, Tallahassee, Florida oDepartment of Psychology, Michigan State University, East Lansing, Michigan pClinical Psychology Program, American School of Professional Psychology at Argosy University, Washington, District of Columbia, USA qRoseneck Hospital for Behavioral Medicine, Prien rDepartment of Psychiatry, University of Munich (LMU), Munich, Germany sCenter for Addiction and Mental Health tDepartment of Psychiatry, Toronto General Hospital, University Health Network uDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada vDepartment of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy wDepartment of Academic Psychiatry, Bermondsey Wing Guys Hospital, University of London, London, UK xBrain Mind Institute EPFL - Lausanne and Center for Psyc

Abstract

No abstract available in PubMed .

Related Concept Videos

Anorexia Nervosa01:28

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
2.0K
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
1.6K
Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
11.3K
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
18.8K
Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
1.1K