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High HCV treatment uptake in the Swedish HIV/HCV co-infected cohort

Jenny Stenkvist1, Ola Weiland, Anders Sönnerborg

  • 1From the Unit of Infectious Diseases, Department of Medicine , Huddinge , Karolinska Institutet , Sweden.

Scandinavian Journal of Infectious Diseases
|July 2, 2014
PubMed

Insights

Hepatitis C virus (HCV) treatment uptake was 25% in Swedish HIV/HCV co-infected patients, comparable to HCV mono-infected individuals. Intravenous drug use was linked to lower HCV treatment initiation.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Hepatitis C virus (HCV) co-infection is a significant cause of mortality in patients with human immunodeficiency virus (HIV).
  • Treatment uptake for HCV is often lower in HIV/HCV co-infected patients compared to those with HCV mono-infection, despite clear indications for treatment.

Purpose of the Study:

  • To assess HCV treatment uptake among HIV/HCV co-infected patients in Sweden.
  • To identify factors influencing the initiation or deferral of HCV treatment in this population.

Main Methods:

  • Analysis of data from 652 HIV/HCV co-infected patients within the Swedish InfCare HIV database (September 2010).
  • Investigation of factors associated with interferon-based HCV treatment initiation.
  • Exploration of patient- and physician-reported reasons for treatment deferral in a subgroup.

Main Results:

  • Prevalence of anti-HCV was 14%, with a chronic HCV infection rate of 11%.
  • HCV treatment was initiated by 25% of co-infected patients.
  • Factors associated with higher treatment rates included HCV genotype 2 or 3, HIV transmission via non-intravenous drug use routes, and ongoing HIV treatment. Intravenous drug use or alcohol abuse were primary reasons for deferring treatment.

Conclusions:

  • The prevalence of anti-HCV in Swedish HIV-infected patients was relatively low internationally.
  • The 25% HCV treatment rate in HIV/HCV co-infected patients was comparable to rates in HCV mono-infected patients in Sweden.
  • Individuals with a history of injecting drug use exhibited the lowest HCV treatment uptake.
Abstract

Keywords:
HCV treatment uptakeHIV/HCV co-infection

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