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Updated: Apr 27, 2026

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Bladder function in patients with dystonia undergoing deep brain stimulation.

Livio Mordasini¹, Thomas M Kessler², Bernhard Kiss³

¹Department of Urology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Parkinsonism & Related Disorders

|July 3, 2014

Summary

Deep brain stimulation (DBS) of the globus pallidus internus improved bladder function in dystonia patients. Pallidal DBS reduced detrusor overactivity, suggesting basal ganglia influence on lower urinary tract control.

Keywords:

Bladder function Deep brain stimulation Dystonia Urodynamics

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Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Area of Science:

Neuroscience
Urology
Movement Disorders

Background:

Neurogenic bladder dysfunction significantly impacts quality of life in Parkinson's disease.
Urinary symptoms and basal ganglia control of the bladder in dystonia are understudied.

Purpose of the Study:

To investigate urinary symptoms in dystonia patients.
To explore the role of the basal ganglia in bladder control via deep brain stimulation (DBS).

Main Methods:

11 dystonia patients undergoing globus pallidus internus DBS were assessed.
Bladder function evaluated using International Prostate Symptom Score and urodynamic investigation (UDI) pre- and post-DBS.

Main Results:

36% of dystonia patients exhibited detrusor overactivity pre-DBS.
Pallidal DBS significantly decreased maximum flow rate and increased post-void residual.
Detrusor overactivity resolved with pallidal DBS ON.

Conclusions:

Pathological urodynamic changes are prevalent in dystonia patients.
Pallidal DBS demonstrates a relaxing effect on detrusor function.
Basal ganglia play a role in lower urinary tract control, offering new therapeutic avenues.