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Resources for Small Regulatory RNAs.

George W Bell1, Fran Lewitter1

  • 1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts.

Current Protocols in Molecular Biology
|July 3, 2014
PubMed
Summary
This summary is machine-generated.

Discovering small regulatory RNAs like siRNAs, miRNAs, and piRNAs has revealed new biological insights. This overview highlights essential databases and tools for researchers working with these crucial RNA molecules.

Keywords:
miRNApiRNAregulatory RNAssiRNA

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Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Recent decades have seen the discovery of novel small regulatory RNA classes.
  • These molecules, including small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs), were previously undetected due to their small size.
  • Their significant roles in gene regulation are now increasingly recognized.

Purpose of the Study:

  • To provide a comprehensive overview of resources for small regulatory RNAs.
  • To guide researchers in utilizing available databases and tools for small RNA analysis.
  • To consolidate information on the rapidly expanding field of small regulatory RNAs.

Main Methods:

  • Literature review of scientific databases and bioinformatics tools.
  • Categorization of resources based on data type and functionality.
  • Synthesis of information on small interfering RNAs, microRNAs, and Piwi-interacting RNAs.

Main Results:

  • Identification of numerous databases storing small regulatory RNA data.
  • Cataloging of various computational tools for analyzing small RNA sequences and functions.
  • Highlighting the accessibility and utility of these resources for the research community.

Conclusions:

  • A wealth of resources now exists to support research on small regulatory RNAs.
  • Effective utilization of these databases and tools is crucial for advancing the field.
  • This overview serves as a valuable guide for navigating the landscape of small RNA research.