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Screening native botanicals for bioactivity: an interdisciplinary approach.

Anik Boudreau¹, Diana M Cheng², Carmen Ruiz¹

¹Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.

Nutrition (Burbank, Los Angeles County, Calif.)

|July 3, 2014

Summary

This summary is machine-generated.

Researchers screened native Louisiana plants from Creole folk medicine, identifying botanical extracts that show potential for treating insulin resistance and inflammation. This study highlights folk medicine as a source for novel therapeutic compounds.

Keywords:

Ethnobotany Inflammation Metabolic syndrome Obesity

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Area of Science:

Ethnobotany
Biochemistry
Endocrinology

Background:

Plant-based therapies are historically significant.
Folk medicine traditions preserve knowledge of plant therapeutic properties.

Purpose of the Study:

Identify native Louisiana Creole folk medicine plants as sources of compounds for treating insulin resistance, type 2 diabetes, and related disorders.

Main Methods:

Interdisciplinary approach: cultural anthropology, botany, biochemistry, endocrinology.
Screened native Louisiana plants based on Creole folk medicine accounts.
Analyzed plant extracts for bioactivity in macrophages and skeletal muscle cells.

Main Results:

Several extracts modulated inflammatory marker gene expression in macrophages.
Identified extracts that alter insulin signaling pathways, specifically protein kinase B phosphorylation, in insulin-resistant muscle cells.

Conclusions:

An interdisciplinary screening of folk medicine plants can identify therapeutic agents.
Native plants hold potential for treating obesity-related insulin resistance and inflammation.