Sleep-disordered breathing and pulmonary function in obese children and adolescents
A Van Eyck1, K Van Hoorenbeeck2, B Y De Winter1
1Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
Sleep Medicine
|July 3, 2014
Summary
Obstructive sleep apnea syndrome (OSAS) in obese children is linked to reduced lung function, including vital capacity and forced expiratory volume. Obesity severity is a key factor influencing both OSAS and pulmonary health.
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Obesity Research
Background:
- Obese children face a higher risk of obstructive sleep apnea syndrome (OSAS).
- OSAS in this population often involves oxygen desaturations, potentially linked to pulmonary function deficits.
Purpose of the Study:
- To investigate the relationship between OSAS and pulmonary function in obese children and adolescents.
- To determine if OSAS severity correlates with specific pulmonary function abnormalities.
Main Methods:
- 185 children were studied, categorized into control, mild OSAS, and moderate-to-severe OSAS groups.
- All participants underwent polysomnography and pulmonary function testing.
Main Results:
- Moderate-to-severe OSAS was associated with significantly decreased vital capacity (VC), forced expired volume in 1s (FEV1), expiratory reserve volume (ERV), total lung capacity, and functional residual capacity (FRC).
- FEV1, FRC, and ERV showed significant correlations with OSAS severity, independent of adiposity.
- Correlations between FEV1/VC and sleep parameters weakened after adjusting for adiposity.
Conclusions:
- A link exists between awake pulmonary function and sleep respiratory parameters in obese children.
- OSAS severity correlates with impaired lung function in obese youth.
- Obesity level is a significant confounder for both OSAS severity and pulmonary function.
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