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Updated: Apr 27, 2026
A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
Hydrogen sulfide detection based on reflection: from a poison test approach of ancient China to single-cell accurate
Hao Kong1, Zhuoran Ma, Song Wang
1Beijing Key Laboratory for Microanalytical Methods and Instrumentation, Department of Chemistry, Center for Atomic and Molecular Nanosciences, Tsinghua University , Beijing 100084, P. R. China.
Abstract:
With the inspiration of an ancient Chinese poison test approach, we report a rapid hydrogen sulfide detection strategy in specific areas of live cells using silver needles with good spatial resolution of 2 × 2 μm(2). Besides the accurate-localization ability, this reflection-based strategy also has attractive merits of convenience and robust response when free pretreatment and short detection time are concerned. The success of endogenous H2S level evaluation in cellular cytoplasm and nuclear of human A549 cells promises the application potential of our strategy in scientific research and medical diagnosis.
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