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Brain endothelial cell targeting via a peptide-functionalized liposomal carrier for xenon hyper-CEST MRI
Matthias Schnurr1, Karl Sydow, Honor May Rose
1ERC Project BiosensorImaging, Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125, Berlin, Germany.
Advanced Healthcare Materials
|July 3, 2014
Abstract:
A nanoparticulate carrier system is used to efficiently deliver a contrast agent for highly sensitive xenon Hyper-CEST MRI. The carrier system not only improves the biocompatibility and solubility of the contrast agent, it also allows selective cell targeting as demonstrated by the discrimination of human brain capillary and aortic endothelial cells.
