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Updated: Apr 27, 2026

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice
Published on: May 4, 2015
[Surgical therapy of myocardial infarction]
Insights
Surgical repair remains crucial for mechanical complications of myocardial infarction (MI). While high-risk, outcomes for surviving patients undergoing coronary artery bypass grafting (CABG) show promising long-term results.
Area of Science:
- Cardiovascular Surgery
- Interventional Cardiology
- Critical Care Medicine
Background:
- Coronary artery bypass grafting (CABG) is increasingly supplanted by percutaneous coronary interventions (PCI) for myocardial infarction (MI).
- Surgical intervention remains the definitive treatment for mechanical complications arising from MI.
- This study evaluates the outcomes of surgical treatment for patients experiencing MI.
Purpose of the Study:
- To assess the results and outcomes of surgical treatment for myocardial infarction (MI).
- To identify the risks and complications associated with surgical repair in acute MI patients.
- To evaluate the long-term prognosis for survivors of surgical MI treatment.
Main Methods:
- A retrospective analysis of 1,959 patients undergoing coronary artery disease surgery between January 2008 and December 2012.
- Focus on 103 patients (5.3%) with acute MI, including those with cardiogenic shock, post-resuscitation, or on ventilation.
- Details on pre-operative PCI, intra-aortic balloon pump use, and timing of surgery relative to MI onset.
Main Results:
- Coronary artery bypass grafting (CABG) was performed in 78 patients; 25 experienced mechanical complications (e.g., papillary muscle rupture, ventricular septal rupture, free wall rupture, left ventricular aneurysm).
- High rates of postoperative complications including arrhythmias, low cardiac output syndrome, and pulmonary issues requiring prolonged ventilation.
- Hospital mortality was 13.4% (14 deaths).
Conclusions:
- Patients with acute myocardial infarction (MI) represent a high-risk surgical cohort.
- Preoperative instability, delayed reperfusion, and hemodynamic compromise from mechanical complications contribute to surgical risks.
- Despite significant postoperative complications and high mortality, long-term follow-up for survivors is encouraging.
Introduction:
Coronary artery bypass grafting (CABG) has been replaced by percutaneous coronary interventions in the treatment of myocardial infarction (MI) nowadays. The surgical repair is the only option for mechanical complications of MI. The aim of our study was to assess the results of surgical treatment of MI.
Patients And Methods:
From January 2008 to December 2012 one thousand nine hundred fifty nine patients were operated on at Centre of cardiovascular surgery and transplantations in Brno for coronary artery disease, 103 (5.3 %) of them suffered from acute MI. The interval between MI and operations was longer than 24 hours in more than half of the patients. Nineteen patients underwent PCI before operation, 32 were in cardiogenic shock with intraaortic balloon pump in 12, twelve patients were after cardiopulmonary resuscitation and 18 were on ventilation.
Results:
CABG alone was performed in 78 patients, in 25 patients mechanical complication of MI occurred; rupture of papillary muscle with mitral regurgitation in 8, rupture of interventricular septum in 11, rupture of free wall of left ventricle in 1 and evolving aneurysm of left ventricle in 5 patients. Several serious complications occurred in the postoperative period; disturbances of heart rhythm, syndrome of low cardiac output and pulmonary complications with the necessity of prolonged ventilation being the most frequent. Fourteen patients died during hospital stay (mortality 13.4 %).
Conclusions:
Patients after acute MI create the highest-risk group for surgical treatment. The reasons comprise serious preoperative status, delayed re-perfusion of ischemic area and serious hemodynamic effect of mechanical complications of MI. A lot of complications may occur during postoperative course and mortality is high. In the survivals the long term follow-up is promising.
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