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Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
Published on: January 4, 2019
Update on biological therapies for knee injuries: osteoarthritis
Guilherme Figueiredo Pintan1, Adilson Sanches de Oliveira, Mario Lenza
1Division of Orthopaedic Surgery, Hospital Israelita Albert Einstein, Avenida Albert Einstein, 627/701 - 3 Andar/Bloco A1, Morumbi, 05651-901, São Paulo, SP, Brazil.
Abstract:
Osteoarthritis (OA) is a progressive disease that causes functional impairment of the joints. Chronic forms of knee OA have been increasing worldwide, limiting patients' quality of life. Recent studies have sought to increase effectiveness and quality in the development of new therapies, such as platelet-rich plasma, hyaluronic acid, stem cells, and nuclear factor κB, aimed principally at reducing proinflammatory activity, pain, and degeneration of the knee joints. The goal of this review is to present an update on biological therapies for knee OA and to provide guidance for future OA studies.
Insights
This review updates on biological therapies for knee osteoarthritis (OA), focusing on treatments like platelet-rich plasma and stem cells to reduce inflammation and joint degeneration. It aims to guide future research for improving patient quality of life.
Area of Science:
- Orthopedics and Regenerative Medicine
- Biomedical Research
Background:
- Osteoarthritis (OA) is a progressive joint disease causing functional impairment.
- Increasing global prevalence of chronic knee OA significantly impacts patient quality of life.
- Current research focuses on novel therapies to mitigate OA progression.
Purpose of the Study:
- To provide an updated overview of biological therapies for knee OA.
- To highlight key treatments targeting inflammation, pain, and degeneration.
- To offer guidance for future osteoarthritis research.
Main Methods:
- Literature review of recent studies on biological therapies for knee OA.
- Analysis of treatments including platelet-rich plasma, hyaluronic acid, stem cells, and nuclear factor κB inhibitors.
- Synthesis of findings related to efficacy in reducing inflammation and degeneration.
Main Results:
- Biological therapies show promise in managing knee OA symptoms.
- Platelet-rich plasma, stem cells, and other agents aim to reduce proinflammatory activity.
- These therapies target the reduction of pain and joint degeneration.
Conclusions:
- Biological therapies represent a growing area of interest for knee OA management.
- Further research is needed to optimize treatment strategies and clinical outcomes.
- This review provides a foundation for future investigations into effective knee OA therapies.
