Related Experiment Video
Updated: Apr 27, 2026
06:20
Murine Bilateral Renal Lymphadenectomy
Published on: December 30, 2025
211
Pyoderma gangrenosum due to lenalidomide use for multiple myeloma
Constantin A Dasanu1, Bruno Bockorny2, Doru T Alexandrescu3
1Department of Medicine, University of Connecticut, Farmington, CT, USA c_dasanu@yahoo.com.
Summary
Pyoderma gangrenosum can occur in multiple myeloma patients. This case suggests lenalidomide therapy may induce or worsen this skin condition, challenging its therapeutic role.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis.
- It is occasionally associated with multiple myeloma (MM), typically in active disease.
- Successful anti-myeloma treatment often leads to PG resolution.
Observation:
- We present a case of PG affecting both knees in a patient with MM.
- The patient was responding to lenalidomide therapy for their multiple myeloma.
- This presentation occurred despite the patient's positive response to treatment.
Findings:
- The occurrence of PG during lenalidomide treatment challenges previous findings on thalidomide derivatives.
- The clinical context suggests lenalidomide may induce or exacerbate PG.
- This contrasts with the expected resolution of PG with effective MM therapy.
Implications:
- Lenalidomide's role in treating PG in MM patients requires further investigation.
- Clinicians should consider PG as a potential adverse effect of lenalidomide.
- Further reports are needed to confirm if this class of drugs can induce PG.
Related Concept Videos
01:26Nephrotic Syndrome II : Assessment and Medical Management
408
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
408
01:24Chronic Kidney Disease II: Clinical Manifestations
1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
01:23Skin Diseases and Disorders
5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
01:24Nephrotic Syndrome III : Nursing Management
547
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
547
01:24Nephrotic Syndrome I : Introduction
1.1K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.1K
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
745
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
745