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High-sensitivity troponin I and amino-terminal pro--B-type natriuretic peptide predict heart failure and mortality in

Paul M McKie1, Omar F AbouEzzeddine2, Christopher G Scott3

  • 1Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, mckie.paul@mayo.edu.

Clinical Chemistry
|July 3, 2014
PubMed

Insights

High-sensitivity cardiac troponin I (cTnI) assays predict heart failure and mortality in the general community. Combining cTnI with NT-proBNP offers complementary prognostic value for identifying at-risk individuals.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Preventive Medicine

Background:

  • High-sensitivity cardiac troponin assays are valuable for prognosis in stable cardiovascular disease.
  • Assessing novel cardiac troponin I (cTnI) high-sensitivity assay utility is crucial for community risk stratification.

Purpose of the Study:

  • To evaluate the prognostic capability of a new high-sensitivity cTnI assay for heart failure and mortality in the general population.
  • To determine if cTnI and amino-terminal pro-B-type natriuretic peptide (NT-proBNP) provide complementary prognostic information.

Main Methods:

  • A community-based cohort of 2042 participants was assessed, with baseline cTnI and NT-proBNP measured in 1843 individuals.
  • Participants were followed for incident heart failure and mortality over a median of 10.7 and 12.1 years, respectively.

Main Results:

  • Elevated high-sensitivity cTnI levels were independently predictive of heart failure (HR 2.56) and mortality (HR 1.91) in the community cohort.
  • High-sensitivity cTnI demonstrated prognostic utility beyond NT-proBNP, with combined use offering enhanced risk identification.

Conclusions:

  • High-sensitivity cTnI assays are effective in predicting heart failure and mortality in community settings.
  • A multimarker approach combining cTnI and NT-proBNP is recommended for identifying high-risk individuals for targeted prevention strategies.
Abstract

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