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Acute hepatic injury with atorvastatin: an unusual occurrence
Pinki Vishwakarma1, Rajiv Nehra2, Alok Kumar3
1Department of Pharmacology, LLRM Medical College, Meerut, Uttar Pradesh, India.
Abstract:
Atorvastatin, a commonly used and well-tolerated hypolipidemic drug, belongs to the class of statins or hydroxymethylglutaryl-coenzyme A reductase inhibitors. Use of atorvastatin may be associated with minor asymptomatic elevations in serum aminotransferases, but clinically significant hepatotoxicity is usually infrequent. Here we present a case of self-limiting clinically apparent acute hepatic injury attributable to atorvastatin occurring at recommended daily dose of 20 mg once a day. This case was postulated to be an unusual idiosyncratic reaction of the drug.
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