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Neuronal intranuclear inclusion disease presenting with resting tremor
Naoyuki Kitagawa1, Jun Sone2, Gen Sobue2
1Department of Neurology, Kohsei Chuo General Hospital, Tokyo Medical University, Tokyo, Japan.
Case Reports in Neurology
|July 3, 2014
Summary
Neuronal intranuclear inclusion disease (NIID) can cause tremors mimicking Parkinson's disease (PD). Skin biopsy confirmed NIID in a patient with tremor unresponsive to PD medications, highlighting NIID in tremor differential diagnosis.
Area of Science:
- Neurology
- Neurodegenerative Diseases
Background:
- Neuronal intranuclear inclusion disease (NIID) is a rare, progressive neurodegenerative disorder.
- NIID presents with diverse neurological symptoms, often challenging diagnosis.
Observation:
- A 73-year-old woman exhibited progressive resting tremor, exacerbated by cognitive tasks and ambulation.
- Parkinsonian features were absent, and tremor did not respond to levodopa or trihexyphenidyl.
- Diagnosis was confirmed via skin biopsy revealing characteristic NIID findings.
Findings:
- The patient's tremor closely resembled the resting tremor seen in Parkinson's disease (PD).
- This case supports previous findings that NIID can manifest with PD-like tremor.
- Skin biopsy is a key diagnostic tool for identifying NIID.
Implications:
- NIID should be considered in the differential diagnosis of patients presenting with resting tremor similar to PD.
- Recognizing NIID's potential to mimic PD is crucial for accurate diagnosis and management.
- Further research into NIID's diverse clinical presentations is warranted.
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