Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

35.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.4K
Next-generation Sequencing03:00

Next-generation Sequencing

87.7K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
87.7K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

119
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
119
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.8K
Sanger Sequencing01:57

Sanger Sequencing

800.5K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
800.5K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

833
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
833

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection.

Scientific reports·2023
Same author

Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection.

Scientific reports·2023
Same author

"It's important to foster open discussion about the topic": development, implementation, and evaluation of an ethics of abortion independent learning module for second year medical students.

Reproductive health·2023
Same author

Trends in Maternal Weight Disparities: Statewide Differences in Rural and Urban Minnesota Residents From 2012 to 2019.

Women's health issues : official publication of the Jacobs Institute of Women's Health·2023
Same author

Let's NOT sleep on it: We epidemiologists can do better about recommendations based on our study findings.

Clinical & experimental ophthalmology·2023
Same author

Associations between <i>CES1</i> variants and dosing and adverse effects in children taking methylphenidate.

Frontiers in pediatrics·2023

Related Experiment Video

Updated: Apr 27, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

36.1K

eMERGEing progress in genomics-the first seven years.

Dana C Crawford1, David R Crosslin2, Gerard Tromp3

  • 1Center for Human Genetics Research, Vanderbilt University Nashville, TN, USA ; Department of Molecular Physiology and Biophysics, Vanderbilt University Nashville, TN, USA.

Frontiers in Genetics
|July 3, 2014
PubMed
Summary

The electronic MEdical Records & GEnomics (eMERGE) network evolved from genomic discovery to implementing genomic information in electronic medical records (EMRs) for improved health. This progression supports next-generation genotype-phenotype studies and clinical applications.

Keywords:
biobankselectronic medical recordsgenome-wide association studiespharmacogenomics

More Related Videos

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
10:19

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project

Published on: April 8, 2017

16.5K
Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
11:02

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Published on: October 18, 2013

19.0K

Related Experiment Videos

Last Updated: Apr 27, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

36.1K
Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
10:19

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project

Published on: April 8, 2017

16.5K
Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
11:02

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Published on: October 18, 2013

19.0K

Area of Science:

  • Genomics
  • Bioinformatics
  • Clinical Informatics

Background:

  • The electronic MEdical Records & GEnomics (eMERGE) network, established in 2007 by NHGRI, aimed to integrate genomic data with electronic medical records (EMRs).
  • Initial efforts focused on genome-wide association studies for genomic discovery.
  • Recent work emphasizes implementing genomic information and clinical decision support into EMRs.

Purpose of the Study:

  • To describe the evolution of the eMERGE network's approach to genomic research.
  • To highlight the development of eMERGE genomic datasets.
  • To outline contributions to genomic discovery, human health, and clinical implementation strategies.

Main Methods:

  • Development and merging of individual eMERGE genomic datasets.
  • Utilizing genome-wide association study (GWAS) paradigms.
  • Evaluating mechanisms for integrating genomic data and clinical decision support into EMRs.

Main Results:

  • The eMERGE network has facilitated significant genomic discovery.
  • The network has contributed to understanding human health through genomic insights.
  • Progress has been made in developing strategies for clinical implementation of genomic data.

Conclusions:

  • The eMERGE network has successfully transitioned from genomic discovery to clinical implementation.
  • The network's datasets and methodologies are crucial for advancing genotype-phenotype association studies.
  • Future directions include next-generation studies and enhanced clinical decision support systems.