Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

43.9K
Overview
43.9K
Teratogenicity01:07

Teratogenicity

4.2K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.2K
Development of Immunocompetence01:22

Development of Immunocompetence

1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K
Vaccines01:21

Vaccines

86
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
86
Vaccine Production01:23

Vaccine Production

129
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
129
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

570
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
570

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A canine macrophage cell line that can be polarized provides a model for canine macrophage differentiation.

Scientific reports·2026
Same author

Design of TOLERANT: phase I/II safety assessment of intranodal administration of HSP70/mB29a self-peptide antigen-loaded autologous tolerogenic dendritic cells in patients with rheumatoid arthritis.

BMJ open·2024
Same author

Characterization of polarization states of canine monocyte derived macrophages.

PloS one·2023
Same author

Overcoming scientific barriers in the transition from <i>in vivo</i> to non-animal batch testing of human and veterinary vaccines.

Expert review of vaccines·2021
Same author

Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccine.

Scientific reports·2021
Same author

Goals in Nutrition Science 2020-2025.

Frontiers in nutrition·2021

Related Experiment Video

Updated: Apr 27, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

3.3K

[Vaccination during pregnancy: safe or not?].

Willem van Eden1

  • 1Universiteit Utrecht, Hoofdafdeling Infectieziekten & Immunologie, Utrecht.

Nederlands Tijdschrift Voor Geneeskunde
|July 3, 2014
PubMed
Summary

Vaccination during pregnancy balances maternal immune responses, protecting both mother and baby. Current evidence suggests the benefits of maternal vaccination outweigh potential risks for infant immunity.

Area of Science:

  • Immunology
  • Maternal-fetal medicine
  • Vaccinology

Background:

  • Pregnancy involves a delicate maternal immune system balance to protect against infection while preventing rejection of the fetus.
  • Vaccines, particularly those with adjuvants, could potentially disrupt this immune balance.
  • Maternal antibodies transferred during pregnancy offer protection to newborns against infectious diseases.

Purpose of the Study:

  • To evaluate the immunological balance during pregnancy in relation to vaccination.
  • To assess the potential risks and benefits of vaccination during pregnancy.
  • To determine if maternal antibody transfer through vaccination provides adequate neonatal protection.

Main Methods:

  • Review of current immunological insights into pregnancy.

More Related Videos

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

18.6K
Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
05:22

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface

Published on: December 30, 2025

420

Related Experiment Videos

Last Updated: Apr 27, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

3.3K
Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

18.6K
Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
05:22

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface

Published on: December 30, 2025

420
  • Analysis of existing data on vaccination during pregnancy.
  • Risk-benefit assessment of maternal immunization strategies.

    • Main Results:

    • Vaccination during pregnancy requires careful consideration of the maternal immune system.
    • The transfer of maternal antibodies to the fetus via vaccination can confer significant neonatal immunity.
    • Potential risks associated with vaccination in pregnancy appear to be outweighed by protective benefits.

    Conclusions:

    • Maternal vaccination strategies are crucial for neonatal infectious disease prevention.
    • The immunological benefits of vaccinating pregnant individuals likely exceed potential adverse effects.
    • Further research into optimizing vaccine safety and efficacy in pregnancy is warranted.