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Related Experiment Videos

Schistosome vaccines: current progress and future prospects.

A Sher1, S L James, R Correa-Oliveira

  • 1Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.

Parasitology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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Vaccine development for schistosomiasis shows promise with identified parasite antigens conferring partial immunity in lab hosts. However, human vaccination requires overcoming challenges in inducing sufficient resistance against schistosome infections.

Area of Science:

  • Parasitology
  • Immunology
  • Vaccine Development

Background:

  • Vaccination against human schistosomes (Schistosoma mansoni, Schistosoma japonicum) is feasible in laboratory settings.
  • Several parasite molecules, including glutathione-S-transferase (P26,28), paramyosin (Sm97), GP38, and GP18, have demonstrated partial protective immunity in animal models.
  • These vaccine candidates are tegument-associated but often have transient or non-essential surface exposure.

Purpose of the Study:

  • To review the properties of promising immunogens for schistosomiasis vaccines.
  • To highlight the challenges and potential impact of human schistosomiasis vaccination.

Main Methods:

  • Review of characterized vaccine molecules and their properties.
  • Discussion of immunization protocols and induced resistance levels.

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Main Results:

  • Identification of diverse parasite antigens (e.g., glutathione-S-transferase, paramyosin) conferring partial immunity in laboratory hosts.
  • Demonstration that current vaccine immunogens and protocols fail to induce sufficient resistance for human application.

Conclusions:

  • While laboratory host vaccination is a reality, significant hurdles remain for human schistosomiasis vaccine development.
  • Overcoming the challenge of inducing adequate resistance is crucial before human trials can be considered, given the immense potential benefit.