Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Metabolism?00:52

What is Metabolism?

109.8K
Overview
109.8K
Overview of Metabolism01:40

Overview of Metabolism

25.6K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
25.6K
Introduction to Metabolism01:30

Introduction to Metabolism

3.1K
Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
3.1K
Metabolism of Chemolithotrophs01:15

Metabolism of Chemolithotrophs

1.3K
Chemolithotrophs are microorganisms that obtain energy by oxidizing inorganic molecules such as hydrogen gas (H₂), ammonia (NH₃), reduced sulfur compounds (H₂S, S²⁻), and ferrous iron (Fe²⁺). Unlike heterotrophic organisms that rely on organic carbon, chemolithotrophs transfer electrons from these inorganic donors to the electron transport chain (ETC), generating a proton motive force (PMF) that drives ATP synthesis through oxidative phosphorylation.
1.3K
Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

3.6K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
3.6K
Drug Biotransformation: Overview01:28

Drug Biotransformation: Overview

6.6K
Biotransformation, also known as drug metabolism, is a vital physiological process that chemically alters drugs, facilitating their elimination from the body and terminating their action. This process involves two main phases: phase I and phase II reactions. Phase I reactions, including oxidation, reduction, and hydrolysis, introduce or unmask polar functional groups on the drug molecule, thereby increasing its water solubility. By enhancing water solubility, the drug becomes more hydrophilic...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reduction of glycation stress as a geroscience intervention: protocol for a pilot RCT in postmenopausal women.

npj aging·2026
Same author

Prioritising mental health research areas for India: A modified delphi-based exercise by the Indian Council of Medical Research.

The Indian journal of medical research·2026
Same author

Deep learning approach for critical exposure during division of the inferior mesenteric artery in colorectal surgery.

Journal of robotic surgery·2026
Same author

Editorial: Digital remote patient monitoring in neurodegenerative diseases.

Frontiers in digital health·2025
Same author

Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence.

Aging·2025
Same author

Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.

Cell reports·2025

Related Experiment Video

Updated: Apr 27, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

1.4K

Mitobolites: the elixir of life.

Subhash D Katewa1, Amit Khanna1, Pankaj Kapahi1

  • 1Buck Institute for Research on Aging, Novato, CA 94945, USA.

Cell Metabolism
|July 3, 2014
PubMed
Summary

A mitochondrial metabolite was found to extend worm lifespan by inhibiting mitochondrial ATPase, mimicking dietary restriction. This discovery offers insights into aging and age-related diseases.

Area of Science:

  • Mitochondrial biology
  • Aging research
  • Metabolomics

Background:

  • Mitochondria play a crucial role in aging and age-related diseases.
  • Understanding the molecular mechanisms linking mitochondria to aging is a significant challenge in biology.

Purpose of the Study:

  • To investigate the role of mitochondrial metabolites in aging.
  • To identify specific metabolites that can influence lifespan and mimic effects of dietary restriction.

Main Methods:

  • Utilized a model organism (worms) to study aging processes.
  • Identified and characterized a specific mitochondrial metabolite.
  • Assessed the effect of the metabolite on mitochondrial ATPase activity.
  • Evaluated the impact of the metabolite on lifespan.

More Related Videos

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis
11:25

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

Published on: July 11, 2014

34.7K
Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems
14:42

Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems

Published on: September 23, 2021

6.7K

Related Experiment Videos

Last Updated: Apr 27, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

1.4K
Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis
11:25

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

Published on: July 11, 2014

34.7K
Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems
14:42

Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems

Published on: September 23, 2021

6.7K

Main Results:

  • A mitochondrial metabolite was identified that inhibits mitochondrial ATPase.
  • This metabolite was shown to extend the lifespan of worms.
  • The mechanism of lifespan extension mimics the effects of dietary restriction.

Conclusions:

  • Mitochondrial metabolites can directly influence aging and lifespan.
  • Inhibition of mitochondrial ATPase by specific metabolites is a potential mechanism for lifespan extension.
  • This finding provides a novel target for interventions against age-related decline.