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Related Concept Videos

Translation01:31

Translation

16.8K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
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Translation01:31

Translation

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Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
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Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Related Experiment Video

Updated: Apr 27, 2026

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
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Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

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[TET2 gene in hematological diseases].

Shuang Li1, Xiao-Qin Wang1

  • 1Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|July 4, 2014
PubMed
Summary

TET2 gene mutations are linked to various blood cancers, suggesting its role in suppressing tumors. This review covers TET2

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Hematology

Background:

  • The TET gene family regulates DNA demethylation and epigenetic processes.
  • TET2 is crucial for normal hematopoiesis (blood cell formation).
  • TET2 mutations are frequently observed in myeloid malignancies.

Purpose of the Study:

  • To review the role of TET2 in hematological malignancies.
  • To summarize recent findings on TET2's function in epigenetics and hematopoiesis.
  • To explore TET2's involvement in various blood cancers.

Main Methods:

  • Literature review of recent studies on TET2.
  • Analysis of TET2's function in DNA demethylation and epigenetics.
  • Examination of TET2's role in bone marrow hematopoietic regulation.

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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Related Experiment Videos

Last Updated: Apr 27, 2026

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
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Main Results:

  • TET2 mutations are implicated in myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS), and leukemia.
  • TET2 acts as a tumor suppressor in the context of hematological malignancies.
  • TET2 plays a significant role in epigenetic regulation within hematopoietic stem cells.

Conclusions:

  • TET2 is a critical player in maintaining normal hematopoiesis.
  • TET2 dysfunction contributes to the development of hematological cancers.
  • Targeting TET2 may offer therapeutic strategies for blood malignancies.