[It's a long way to go to apprehend wound repair]

Wound healing is a complicated process, involving the activity of multiple cells and various cytokines. Chronic wound or intractable wound has already become a big challenge for clinicians. There are imbalances in the healing process of chronic wound, such as inflammatory response, cell proliferation, and remodeling of extracellular matrix. Combination of tissue transplantation and vacuum sealing drainage may be the optimum selection for wound repair. Besides the chronic wound, more attention should be paid to experimental and clinical studies on early-stage of healing of fresh wound and granulation wound in middle and late stages.