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Chronic liver disease. A case control study of the effect of previous blood transfusion

G M Wood, L J Levy, M S Losowsky

    Public Health
    |March 1, 1989
    PubMed

    Insights

    This study found no clear evidence that blood transfusions cause chronic liver disease in Britain. The investigation highlighted the need for improved transfusion history recall in patients for future risk assessments.

    Area of Science:

    • Hepatology
    • Infectious Diseases
    • Epidemiology

    Background:

    • Hepatitis NANB virus (HNV) infection transmitted via blood transfusion is a potential cause of chronic liver disease.
    • Assessing the role of blood transfusions in chronic liver disease requires accurate patient histories.

    Purpose of the Study:

    • To investigate blood transfusion as a cause of non-A, non-B hepatitis (NANB) and chronic liver disease in England.
    • To evaluate the reliability of patient transfusion histories.

    Main Methods:

    • A case-control study comparing patients with chronic liver disease to matched controls.
    • Detailed medical histories, including operations and blood transfusions within ten years, were collected.
    • Hospital records were used to verify transfusion histories.

    Main Results:

    • No significant difference in transfusion history was found between chronic liver disease patients and controls.
    • Male patients with chronic liver disease were more likely to have resided in the Middle or Far East.
    • Excluding patients with this travel history did not yield statistically significant differences in transfusion rates.

    Conclusions:

    • The study found no clear evidence of blood transfusion being a major cause of chronic liver disease in Britain.
    • The methodology, focusing on confirmed transfusion histories in newly diagnosed patients, can be adapted for ongoing risk assessment.

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