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Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Apr 27, 2026

Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy

Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy

Published on: August 28, 2013

Gold nanoparticle hyperthermia reduces radiotherapy dose.

James F Hainfeld¹, Lynn Lin², Daniel N Slatkin²

¹Nanoprobes, Inc., Yaphank, NY, USA.

Nanomedicine : Nanotechnology, Biology, and Medicine

|July 4, 2014

Summary

Gold nanoparticles enhance cancer treatment by combining near-infrared light heating and X-ray therapy. This synergy significantly reduces required radiation doses, improving efficacy and minimizing side effects.

Keywords:

Cancer Gold nanoparticles Hyperthermia Radiotherapy

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In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System

In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System

Published on: July 2, 2020

Area of Science:

Nanotechnology
Biomedical Engineering
Oncology

Background:

Gold nanoparticles absorb near-infrared light, enabling tumor hyperthermia and ablation.
Gold nanoparticles enhance X-ray dose deposition in tumors.
Combining hyperthermia and radiotherapy offers synergistic therapeutic benefits.

Purpose of the Study:

To investigate the synergistic effects of gold nanoparticles, near-infrared hyperthermia, and X-ray radiotherapy.
To evaluate the efficacy of this combined approach in a radioresistant tumor model.

Main Methods:

Intratumoral infusion of 15 nm gold nanoparticles engineered for infrared absorption.
Tumor heating using near-infrared light followed by X-ray treatment.
Assessment of tumor control in a murine squamous cell carcinoma (SCCVII) model.

Main Results:

A significant reduction in the X-ray dose required for 50% tumor control was observed.
The required X-ray dose decreased from 55 Gy to <15 Gy, a factor of >3.7.
Demonstrated the synergistic effect of combining gold nanoparticle-mediated hyperthermia with radiotherapy.

Conclusions:

Gold nanoparticles facilitate a combined hyperthermia and radiotherapy approach.
This method drastically reduces the necessary X-ray dose, sparing normal tissues.
Enhanced therapeutic outcomes and reduced side effects are potential benefits for radiotherapy.