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Severe iron-deficiency anemia still an issue in toddlers
Gabrielle Paoletti1, Debra L Bogen2, A Kim Ritchey3
1University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Insights
Severe iron-deficiency anemia (IDA) remains a significant health issue in toddlers, strongly linked to excessive cow's milk intake. Early screening for IDA is crucial for continued toddler health and development.
Area of Science:
- Pediatric Hematology
- Nutritional Anemia
- Child Development
Background:
- Chronic, severe iron-deficiency anemia (IDA) in early childhood poses risks for irreversible developmental deficits.
- While infant IDA has declined, toddlers (13-36 months) remain vulnerable.
- Excessive cow's milk consumption is a suspected contributor to IDA in toddlers.
Purpose of the Study:
- To assess the prevalence of severe IDA in toddlers.
- To investigate the association between severe IDA and high cow's milk intake in this age group.
- To emphasize the need for continued IDA screening in toddler care.
Main Methods:
- Retrospective chart review of children aged 6-36 months.
- Inclusion criteria: severe microcytic anemia (hemoglobin <9 g/dL, MCV <75 fL).
- Data collected on demographics, symptoms, physical findings, and dietary intake (cow's milk).
Main Results:
- 68 children with severe IDA identified; 84% were toddlers (13-36 months).
- Mean hemoglobin was 6.0 g/dL, mean MCV was 54.0 fL.
- Excessive cow's milk intake (>24 oz/day) was reported in 47 of 48 children with intake data.
Conclusions:
- Severe IDA persists as a significant problem in toddlers, despite public health efforts.
- High cow's milk consumption strongly correlates with severe IDA in this population.
- Routine screening for IDA is essential for toddler healthcare.
Background And Objectives:
Chronic, severe iron-deficiency anemia (IDA) in the first years of life increases the risk of irreversibly compromised cognitive, affective, and motor development. While IDA in infants has decreased because of dietary changes (iron-fortified formula and delaying cow's milk), toddlers (13-36 months) are equally vulnerable to the adverse effects of IDA. We aimed to show that despite public health efforts, severe IDA remains a problem in toddlers and is associated with excess milk consumption.
Methods:
Retrospective chart review of children 6 to 36 months admitted to or evaluated by hematology at a children's hospital from January 1, 2005 to December 31, 2010 with a severe microcytic anemia (hemoglobin [Hb] <9 g/dL and mean corpuscular volume (MCV) <75 fL).
Results:
We identified 68 infants and toddlers with severe IDA; most (84%) were 13 to 36 months old. The mean Hb and MCV were 6.0 g/dL (range = 2.2-8.9 g/dL) and 54.0 fL (range = 45.5-69.8 fL), respectively. Fatigue, poor appetite, and pica were the most common symptoms, found in 43%, 29%, and 22% of patients, respectively. Only 41% of parents reported pale skin while 77% of physicians recorded it on physical exam. Daily cow's milk consumption surpassed 24 ounces for 47 of 48 children with reported intake; 11 consumed more than 64 ounces per day.
Conclusions:
Despite current screening recommendations, severe IDA continues to be a problem in toddlers and strongly correlates with excess cow's milk consumption. This reiterates the importance of screening for IDA into routine toddler care.
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