Severe iron-deficiency anemia still an issue in toddlers

Gabrielle Paoletti1, Debra L Bogen2, A Kim Ritchey3

  • 1University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Clinical Pediatrics
|July 4, 2014
PubMed

Insights

Severe iron-deficiency anemia (IDA) remains a significant health issue in toddlers, strongly linked to excessive cow's milk intake. Early screening for IDA is crucial for continued toddler health and development.

Area of Science:

  • Pediatric Hematology
  • Nutritional Anemia
  • Child Development

Background:

  • Chronic, severe iron-deficiency anemia (IDA) in early childhood poses risks for irreversible developmental deficits.
  • While infant IDA has declined, toddlers (13-36 months) remain vulnerable.
  • Excessive cow's milk consumption is a suspected contributor to IDA in toddlers.

Purpose of the Study:

  • To assess the prevalence of severe IDA in toddlers.
  • To investigate the association between severe IDA and high cow's milk intake in this age group.
  • To emphasize the need for continued IDA screening in toddler care.

Main Methods:

  • Retrospective chart review of children aged 6-36 months.
  • Inclusion criteria: severe microcytic anemia (hemoglobin <9 g/dL, MCV <75 fL).
  • Data collected on demographics, symptoms, physical findings, and dietary intake (cow's milk).

Main Results:

  • 68 children with severe IDA identified; 84% were toddlers (13-36 months).
  • Mean hemoglobin was 6.0 g/dL, mean MCV was 54.0 fL.
  • Excessive cow's milk intake (>24 oz/day) was reported in 47 of 48 children with intake data.

Conclusions:

  • Severe IDA persists as a significant problem in toddlers, despite public health efforts.
  • High cow's milk consumption strongly correlates with severe IDA in this population.
  • Routine screening for IDA is essential for toddler healthcare.
Abstract

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
1.0K
Microbes and Other Elemental Cycles01:24

Microbes and Other Elemental Cycles

Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
86
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.6K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
1.1K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.6K
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
4.1K