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Updated: Apr 27, 2026

Biochemical Measurement of Neonatal Hypoxia
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Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

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Addressing the burden of neonatal hyperbilirubinaemia in countries with significant glucose-6-phosphate dehydrogenase

Bolajoko O Olusanya1, Abieyuwa A Emokpae2, Tara G Zamora3

  • 1Centre for Healthy Start Initiative, Ikoyi, Lagos, Nigeria.

Acta Paediatrica (Oslo, Norway : 1992)
|July 4, 2014
PubMed

Insights

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a global risk for severe jaundice. In low- and middle-income countries, this condition is linked to neonatal death and developmental issues.

Area of Science:

  • Medical Research
  • Public Health
  • Genetics

Background:

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a known risk factor for severe hyperbilirubinaemia worldwide.
  • Neonatal jaundice is a significant concern, particularly in resource-limited settings.

Purpose of the Study:

  • To examine the patterns and management of severe hyperbilirubinaemia in low- and middle-income countries (LMICs).
  • To assess the association between G6PD deficiency and severe hyperbilirubinaemia outcomes in LMICs.

Main Methods:

  • Literature review of studies conducted in LMICs.
  • Analysis focused on regions where G6PD deficiency prevalence is 10% or higher.

Main Results:

  • Severe hyperbilirubinaemia in LMICs with high G6PD deficiency rates is frequently associated with neonatal mortality.
  • Neurodevelopmental disorders are also commonly linked to severe hyperbilirubinaemia in these populations.

Conclusions:

  • LMICs require immediate focus on G6PD deficiency to reduce jaundice-related harm.
  • Addressing G6PD deficiency is crucial to prevent avoidable morbidity, mortality, and disability from jaundice.
Abstract

Keywords:
Acute bilirubin encephalopathyChild disabilityDeveloping countriesKernicterusPhototherapy

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