Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

1.0K
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
1.0K
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

2.0K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
2.0K
Endotracheal Intubation II: Nursing Management01:17

Endotracheal Intubation II: Nursing Management

3.8K
Endotracheal intubation is a critical procedure that can be lifesaving for many patients with respiratory distress or failure. The role of nursing in managing endotracheal tubes is pivotal, as it involves pre-intubation preparation, assisting during the procedure, and post-extubation care.
1. Nursing Care of Patients Before Intubation
Before the endotracheal intubation procedure, nurses play an essential role in ensuring the process goes smoothly. The nurses must be familiar with intubation...
3.8K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.7K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Widefield OCT angiography" [Progress in Retinal and Eye Research. 107 (2025) 101378].

Progress in retinal and eye research·2025
Same author

Widefield OCT angiography.

Progress in retinal and eye research·2025
Same author

A system for producing controlled elevation of intraocular pressure in awake Brown Norway rats.

Experimental eye research·2025
Same author

112° field of view high-resolution swept-source OCT angiography for rat retinas.

Optics letters·2024
Same author

Controlled Elevation of Intraocular Pressure (CEI) Glaucoma Model in Rats.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Controlled elevation of intraocular pressure in anesthetized mice.

Experimental eye research·2024
Same journal

Retraction statement: rupture of the pregnant uterus - a 20-year review.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Retraction statement: a new conservative surgical approach for placenta accreta spectrum in a low-resource setting.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Response to the letter regarding "cervical length and fetal fibronectin for the identification of true spontaneous onset of labor".

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Paternal age and adverse pregnancy outcomes: a spline analysis from the nulliparous pregnancy outcomes study: monitoring mothers-to-be study.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Maternal and neonatal outcomes of forceps delivery in women undergoing trial of labor after cesarean.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Evaluating and optimizing retinal examination methods for diagnosing retinopathy of prematurity in premature infants.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs
05:40

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

Published on: December 22, 2023

735

Tocolysis for acute preterm labor: does anything work.

Kjell Haram1, Jan Helge Seglem Mortensen, John C Morrison

  • 1Department of Obstetrics and Gynecology, Haukeland University Hospital , Bergen , Norway .

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|July 4, 2014
PubMed
Summary
This summary is machine-generated.

Tocolysis for preterm labor aims to delay birth, but only some agents like nifedipine significantly improve neonatal outcomes. Prolonged use is not recommended, and benefits vary among different tocolytic medications.

Keywords:
Atosibanbeta-mimeticcalcium channel blockersindomethacinmagnesium sulfatenitroglycerinepreterm deliverytocolytics

More Related Videos

Laparoscopic Extracorporeal Knot-Tying for Uterine Vessel Occlusion during Hysterectomy with Cervical Cerclage in Large Uteri
05:21

Laparoscopic Extracorporeal Knot-Tying for Uterine Vessel Occlusion during Hysterectomy with Cervical Cerclage in Large Uteri

Published on: September 12, 2025

823
External Cephalic Version: Is it an Effective and Safe Procedure?
08:49

External Cephalic Version: Is it an Effective and Safe Procedure?

Published on: June 6, 2020

15.4K

Related Experiment Videos

Last Updated: Apr 27, 2026

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs
05:40

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

Published on: December 22, 2023

735
Laparoscopic Extracorporeal Knot-Tying for Uterine Vessel Occlusion during Hysterectomy with Cervical Cerclage in Large Uteri
05:21

Laparoscopic Extracorporeal Knot-Tying for Uterine Vessel Occlusion during Hysterectomy with Cervical Cerclage in Large Uteri

Published on: September 12, 2025

823
External Cephalic Version: Is it an Effective and Safe Procedure?
08:49

External Cephalic Version: Is it an Effective and Safe Procedure?

Published on: June 6, 2020

15.4K

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Pharmacology

Background:

  • Preterm labor (PTL) necessitates interventions to delay delivery, enabling maternal transfer and fetal lung maturation via corticosteroids.
  • Current tocolytic agents have varying efficacy in delaying birth and improving neonatal outcomes.

Purpose of the Study:

  • To evaluate the effectiveness of different tocolytic agents in delaying delivery and improving neonatal outcomes in preterm labor.
  • To assess the safety profiles and optimal use of various tocolytic medications.

Main Methods:

  • Review of existing literature on tocolysis for preterm labor.
  • Comparative analysis of different drug classes including beta-mimetics, calcium channel blockers, atosiban, magnesium sulfate, indomethacin, and transdermal nitroglycerin.

Main Results:

  • Beta-mimetics delay birth within 48 hours but do not improve neonatal outcomes.
  • Calcium channel blockers, particularly nifedipine, significantly delay delivery and decrease adverse neonatal outcomes.
  • Atosiban offers good maternal-fetal safety but limited neonatal benefits. Magnesium sulfate is primarily neuroprotective. Indomethacin is suitable for acute use <32 weeks gestation, avoiding prolonged use.
  • Transdermal nitroglycerin may reduce neonatal morbidity by preventing early preterm birth.

Conclusions:

  • Nifedipine is a reasonable first-choice tocolytic due to ease of administration and limited side effects compared to beta-mimetics.
  • Tocolysis generally does not extend gestational age beyond seven days.
  • The choice of tocolytic agent should consider specific neonatal benefits, maternal-fetal safety, and gestational age.