Related Experiment Video
Updated: Apr 27, 2026
06:21
Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
9.7K
Aleukaemic leukaemia presenting with pathological fracture
Gilbert T Chua1, Kam Ching Chow2, Jason Chi Chiu So3
1Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Hong Kong, Hong Kong.
BMJ Case Reports
|July 4, 2014
Summary
A rare case of precursor B-cell acute lymphoblastic leukemia was diagnosed in a young girl presenting with a bone fracture. Cytogenetic analysis confirmed the diagnosis, revealing a hyperdiploid clone.
Area of Science:
- Pediatric Oncology
- Hematology
- Cytogenetics
Background:
- Acute lymphoblastic leukemia (ALL) is a common childhood cancer.
- Early diagnosis is crucial for effective treatment and improved outcomes.
- Diagnostic challenges can arise in atypical presentations.
Observation:
- A 19-month-old girl presented with a pathological fracture of the distal tibia.
- Initial peripheral blood, electrolytes, and bone biopsy were unremarkable for malignancy.
- Bone marrow morphology and immunohistochemistry were inconclusive for acute leukemia.
Findings:
- Cytogenetic study definitively diagnosed precursor B-cell acute lymphoblastic leukemia.
- The leukemia clone exhibited hyperdiploidy with trisomies, including gain of chromosome 4.
- This confirmed the diagnosis despite initial ambiguous findings.
Implications:
- Highlights the importance of advanced cytogenetic studies in diagnosing pediatric ALL.
- Underscores the need for comprehensive diagnostic approaches in challenging cases.
- Provides insights into the genetic landscape of pediatric precursor B-cell ALL.
Related Concept Videos
01:27Disorders of Leukocytes
2.3K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.3K
01:27Fractures: Bone Repair
5.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.8K