Related Experiment Video

Updated: Apr 27, 2026

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
10:31

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

Published on: September 26, 2025

670

Thematic minireview series on phospholipase D and cancer

Julian Gomez-Cambronero1, George M Carman2

  • 1Department of Biochemistry and Molecular Biology, Wright State University School Medicine, Dayton, Ohio 45435 and.

The Journal of Biological Chemistry
|July 4, 2014
PubMed

Insights

Phospholipase D (PLD) signaling is crucial for cell functions and migration. Emerging evidence links PLD to cancer, highlighting its potential as a therapeutic target for various diseases.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Biochemistry

Background:

  • Phospholipase D (PLD) signaling is integral to fundamental cellular processes including growth, proliferation, and vesicular transport.
  • PLD and its product, phosphatidate, directly influence the actin cytoskeleton and cellular migration.
  • Cellular motility is a key driver of cancer invasion and metastasis, positioning PLD as a significant factor in cancer research.

Discussion:

  • This review series explores the molecular mechanisms underlying PLD's emerging role in tumorigenesis.
  • The influence of the tumor microenvironment on PLD activity and cancer progression is examined.
  • Potential links between PLD signaling and inflammatory pathways in cancer are discussed.

Key Insights:

  • PLD signaling pathways are implicated in promoting cancer cell motility and invasion.
  • The tumor microenvironment modulates PLD activity, affecting cancer cell behavior.
  • PLD's involvement in inflammation suggests a multifaceted role in cancer development.

Outlook:

  • PLD represents a promising molecular target for novel anti-cancer therapeutic strategies.
  • Understanding PLD signaling may lead to treatments for other diseases beyond cancer.
  • Further research into PLD's interactions could unlock new avenues for drug development.
Keywords:
CancerInflammationLipid SignalingPhosphatidatePhospholipase D

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