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Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
Published on: October 3, 2010
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Local control in non-metastatic medulloblastoma
Kaitlin M Christopherson1, Julie A Bradley, Ronny L Rotondo
1Department of Radiation Oncology, University of Florida , Gainesville, Florida , USA.
Acta Oncologica (Stockholm, Sweden)
|July 4, 2014
Summary
Long-term medulloblastoma radiotherapy outcomes show chemotherapy and shorter treatment duration improve local control (LC). Modern dose reductions did not compromise disease control, suggesting chemotherapy
Area of Science:
- Pediatric Oncology
- Radiation Oncology
- Neuro-oncology
Background:
- Review of long-term outcomes for non-metastatic medulloblastoma treated with radiotherapy.
- Analysis of factors influencing local control (LC).
Purpose of the Study:
- To evaluate long-term outcomes and local control (LC) in children with non-metastatic medulloblastoma treated with radiotherapy.
- To identify factors affecting local control (LC) in medulloblastoma patients.
Main Methods:
- Retrospective review of 50 children (M0 medulloblastoma) treated with radiotherapy between 1963-2008.
- Analysis of craniospinal and posterior fossa radiation doses, surgical resection extent, and chemotherapy use.
- Long-term follow-up for overall survival, cancer-specific survival, progression-free survival, and local control (LC).
Main Results:
- 10-year local control (LC) rate was 84%.
- Chemotherapy use was associated with a 10-year LC rate of 100% vs. 76% without chemotherapy (p=0.0454).
- Radiotherapy duration ≤ 45 days was linked to a superior 10-year LC rate of 95% vs. 73% for longer durations (p=0.0419).
Conclusions:
- Reductions in craniospinal dose and boost target volume for toxicity reduction have not compromised disease control.
- Radiotherapy duration, not the interval between surgery and radiotherapy, appears to be a key factor for local control (LC).
- Chemotherapy may play a significant, underappreciated role in improving local control (LC) for medulloblastoma.
