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Updated: Apr 27, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Acetate and acetamide complexes of [Ni(Me4[12]aneN4)]PF6: a tale of two ligands
Jessica L Wallick1, Charles G Riordan1, Glenn P A Yap1
1Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Abstract:
Although there are many examples of acetate complexes, acetamide complexes are virtually unknown. A side-by-side comparison in (acetato-κ(2)O,O')(1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane-κ(4)N)nickel(II) hexafluoridophosphate, [Ni(C2H3O2)(C12H28N4)]PF6, (1), and (acetamidato-κ(2)O,O')(1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane-κ(4)N)nickel(II) hexafluoridophosphate, [Ni(C2H4NO)(C12H28N4)]PF6, (2), shows the steric equivalence between these two ligands, suggesting that acetamide could be considered as a viable acetate replacement for electronic tuning.
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