Related Experiment Video
Updated: Apr 27, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
A 2-year-old girl with a recurrent vesicular rash
Mary K Paul1, Christopher Chang
1Division of Allergy and Immunology, Thomas Jefferson University, A.I. duPont Hospital for Children, Wilmington, Delaware, USA.
Abstract:
Rashes related to viral infection are a relatively common occurrence in pediatrics. We present the unusual case of a 2-year-old girl referred for evaluation of recurrent rashes thought to be caused by Varicella zoster. She had no systemic symptoms of Varicella infection and otherwise had a benign immune history. The rashes were responsive to treatment with acyclovir. However, she did not have detectable IgG antibody to Varicella zoster. Relevant immunology labs were sent, which led to the diagnosis. The patient was started on prophylactic acyclovir and has since been doing well with only one minor recurrence of the rash. This case illustrates the importance of a detailed immune assessment in the evaluation of unusually severe, recurrent, or atypical pediatric exanthems.
More Related Videos
08:04Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
09:01An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Related Concept Videos
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Endocarditis II: Clinical Features of Infective Endocarditis
Rheumatic Heart Disease I: Introduction
Diphtheria
Cytomegalovirus Disease
Bacterial Gastroenteritis