Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Preparedness and Phobias01:09

Preparedness and Phobias

476
Human fear responses to certain stimuli, such as darkness, heights, deep water, and blood, can often arise despite the absence of direct negative experiences. This phenomenon is rooted in evolutionary psychology, which posits that humans have developed a predisposition to fear stimuli that historically posed significant survival threats. This predisposition, known as preparedness, suggests that early humans who developed a fear of potentially dangerous entities, such as venomous snakes and...
476
Avoidance Learning and Learned Helplessness01:14

Avoidance Learning and Learned Helplessness

4.2K
Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of endothelial Dlc1 in embryonic vascular development and adult bone marrow hematopoiesis.

Leukemia·2026
Same author

Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticity.

bioRxiv : the preprint server for biology·2026
Same author

TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine.

Science advances·2026
Same author

Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets.

Cell·2026
Same author

Advances in neuropsychiatry: From objective diagnostics to mechanism-based therapeutics.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026
Same author

BRAF V600E Expression in c-Kit+ Interstitial Cells of Cajal Drives Gastrointestinal Stromal Tumor Formation in Mice.

Cancer research communications·2026

Related Experiment Video

Updated: Apr 27, 2026

Contextual and Cued Fear Conditioning Test Using a Video Analyzing System in Mice
19:32

Contextual and Cued Fear Conditioning Test Using a Video Analyzing System in Mice

Published on: March 1, 2014

53.5K

BDNF modulates contextual fear learning during adolescence.

Iva Dincheva1, Siobhan S Pattwell, Lino Tessarollo

  • 1Department of Psychiatry, Weill Cornell Medical College of Cornell University, New York, N.Y., USA.

Developmental Neuroscience
|July 5, 2014
PubMed
Summary
This summary is machine-generated.

The BDNF Val66Met gene variant impacts fear learning by altering hippocampal function. This variant affects contextual fear expression, particularly during adolescence and adulthood, highlighting BDNF-TrkB signaling

More Related Videos

Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder
05:49

Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

Published on: October 13, 2018

11.4K
Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker
08:32

Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker

Published on: December 18, 2014

25.3K

Related Experiment Videos

Last Updated: Apr 27, 2026

Contextual and Cued Fear Conditioning Test Using a Video Analyzing System in Mice
19:32

Contextual and Cued Fear Conditioning Test Using a Video Analyzing System in Mice

Published on: March 1, 2014

53.5K
Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder
05:49

Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

Published on: October 13, 2018

11.4K
Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker
08:32

Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker

Published on: December 18, 2014

25.3K

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • Brain-derived neurotrophic factor (BDNF) is crucial for emotional and cognitive functions, including fear learning and memory.
  • The BDNF Val66Met single-nucleotide polymorphism (SNP) is linked to reduced BDNF secretion and impaired fear learning.
  • Adolescence is a critical period for the onset of anxiety and fear-related disorders.

Purpose of the Study:

  • To investigate the impact of the BDNF Val66Met SNP on fear learning during adolescent development.
  • To explore the role of BDNF-TrkB signaling in modulating hippocampal-dependent contextual fear learning during adolescence.

Main Methods:

  • Utilized BDNF Val66Met knock-in mice and truncated TrkB receptor (TrkB.T1)-deficient mice.
  • Assessed contextual fear learning and expression across adolescent and adult stages.
  • Compared fear responses between genetically modified mice and wild-type controls.

Main Results:

  • BDNF Val66Met mice showed no altered contextual fear during adolescence but failed to display delayed fear expression in adulthood.
  • This suggests the Met allele may cause persistent alterations in hippocampal function, mimicking adolescent states.
  • TrkB.T1(-/-) mice exhibited accelerated contextual fear expression during adolescence compared to controls.

Conclusions:

  • BDNF-TrkB signaling plays a critical role in regulating fear responses in vivo.
  • This signaling is particularly important during the sensitive developmental period of adolescence.
  • The BDNF Val66Met SNP may lead to long-term changes in hippocampal function affecting fear memory.