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Updated: Apr 27, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Protein-protein interactions and human cellular cofactors as new targets for HIV therapy
Cristina Tintori1, Annalaura Brai1, Anna Lucia Fallacara2
1Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Abstract:
Two novel approaches for the development of new drugs against AIDS are summarized each leading to the achievement of important discoveries in anti-HIV therapy. Despite the success of HAART in reducing mortality, resistant strains continue to emerge in the clinic, underscoring the importance of developing next-generation drugs. Protein-protein interactions and human cellular cofactors represent the new targets of tomorrow in HIV research. The most relevant results obtained in the last few years by the two new strategies are described herein.
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