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Induction of Leptomeningeal Cells Modification Via Intracisternal Injection
Published on: May 7, 2020
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Infliximab-induced aseptic meningitis.
Rushikesh Shah1, Mili Shah2, Nidhi Bansal3
1SUNY Upstate Medical University, 50 Presidential Plaza, Syracuse, NY 13202.
The American Journal of Emergency Medicine
|July 5, 2014
Summary
Aseptic meningitis is a rare side effect of infliximab, a biologic drug used for autoimmune diseases. Early recognition is crucial for prompt diagnosis and management of this serious adverse event.
Area of Science:
- Immunology
- Neurology
- Pharmacology
Background:
- Infliximab is a widely prescribed biologic therapy for autoimmune conditions.
- While generally safe, it carries risks of rare but severe adverse events.
- Aseptic meningitis is an uncommon neurological complication associated with infliximab.
Observation:
- A case report details a middle-aged patient experiencing fever and headache shortly after initiating infliximab.
- Diagnostic workup confirmed infliximab-induced aseptic meningitis.
- This represents the fifth reported instance in medical literature.
Findings:
- Infliximab-induced aseptic meningitis can present atypically, potentially leading to diagnostic delays.
- Prompt identification and discontinuation of infliximab are essential.
Implications:
- Increased physician awareness of this rare side effect is critical.
- Early diagnosis and management can prevent severe neurological sequelae.
- This case highlights the importance of considering drug-induced meningitis in patients on infliximab therapy.
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